Very exciting novel developments have been made regarding the use of VLPs as display platforms, not only for pathogen-derived antigens such as CSP displayed on HBsAg for immunization against malaria but also against self-molecules, such as Aβ for vaccines against Alzheimer’s disease or cytokines for the treatment of chronic diseases in companion animals and humans. This evidence concerns the gene DNAJC5 and early-onset autosomal dominant Alzheimer disease.