Since TBK1 and IKKε are activated by obesity-related inflammation and BJ directly inhibits IKKε and TBK1, the reduction in inflammation observed after BJ treatment in this study may be partiallyly and indirectly related due to the indirect effect of improving to the alleviation of metabolic disease. The gene discussed is IKBKE; the disease is obesity due to melanocortin 4 receptor deficiency.