PINK1 and acute kidney injury: In this study, the key mitophagy enzyme PINK1 was induced by gene transfection and overexpressed in BMSCs to optimize the ability of these cells to resist damage under IRI-AKI conditions, which exerted effects on renal protection by improving the survival and differentiation of BMSCs under IRI-AKI conditions, regulating mitophagy and maintaining mitochondrial homeostasis, jointly enhancing BMSC-mediated repair of IRI-AKI, and then exerting a protective effect on renal function.