As Liang Q et al. claimed through their study on mice, cardiac hypertrophy may be present as a result of the overexpression of GATA4 or GATA656,57, while the cardiomyocyte-specific conditional deletion of GATA6 can cause a significantly reduced hypertrophic response to the stimulation of pressure overload, rapidly leading to heart failure. Here, GATA4 is linked to heart failure.