We observed a modest but significant type I (IFN-α) and II (IFN-γ) interferon response in some of the IAV (alveolar and tracheobronchial ALI tissues) and SARS-CoV-2 (tracheobronchial ALI tissue) infected ALI tissues compared to the uninfected controls (Fig. 7b). Here, IFNA1 is linked to acute respiratory distress syndrome.