Intra-renal expression levels of Sirt1, Sirt3, Sirt6, and Nmnat1 were evaluated in specimens from 27 patients who were histologically diagnosed with FSGS (Supplementary Table 1, Supplementary Fig. 1) and IgA nephropathy (Supplementary Table 2, Supplementary Fig. 2). Here, SIRT3 is linked to focal segmental glomerulosclerosis.