To investigate whether Il-1r1 deficiency rescues Tet2-associated hematological malignancies in a cell autonomous manner, we performed a competitive transplantation of BM containing HSPCs from C57 (CD45.2), Boy/J (CD45.1), Tet2−/− (CD45.2), Il-1r1−/− (CD45.2), and Tet2−/−;Il-1r1−/− (CD45.2) donor mice into CD45.1- and CD45.2-expressing F1 recipient mice and evaluated the effects of Il-1r1 loss on engraftment and on Tet2−/− HSPCs and mature hematopoietic cell types (Supplementary Fig. 2A). This evidence concerns the gene TET2 and hematologic disorder.