Most CGs are closely related to cancer and can be used as molecular markers for clinical diagnosis and therapeutic targets, such as BCR-ABL in chronic myelogenous leukemia, ETV6-NTRK3 in secretory BC4, MYB-NFIB in adenoid cystic carcinoma44, and EML4-ALK in lung cancer45,46. This evidence concerns the gene ALK and chronic myelogenous leukemia, BCR-ABL1 positive.