As released extracellular HMGB1 can induce considerable inflammation and has demonstrated to cause detrimental effects globally in various disease states [141], many therapeutic strategies have been employed, supporting that targeting HMBG1 can improve outcomes in sepsis (including neutralizing antibodies, HMGB1 antagonists, and small inhibitory peptides) [6, 7]. Here, HMGB1 is linked to Sepsis.