PLK1 and neoplasm: Although our findings revealed tRiMetF31 to be a crucial component of the miR-34a tumor suppressor network, we noted that the enforced expression of miR-34a itself also weakened the expression of PLK1, SNAIL, VEGFA, and NOTCH1, which are validated targets of miR-34a, that may also contribute to miR-34a-induced suppression in migration and angiogenesis.