Interestingly, this revealed clear differences in the top 200 most variable genes (Fig. 6a) and provided evidence that our model is similar to DHL/DLBCL as evidenced by upregulation of pathways (e.g. DLBCL, MYC) and specific genes (e.g. Ep300, Stat6) that are observed in human DHL (Fig. 6b, Supplementary Table 2 and Supplementary Data 1)37. The gene discussed is EP300; the disease is diffuse large B-cell lymphoma.