Interestingly, comparing the BCL-2 levels of Eμ-Myc/Eμ-Bcl-2 lymphomas (note this is human BCL-2) with our Eμ-Myc/dCas9a-SAMKI/+/sgBcl-2 lymphomas revealed no detectable differences in the primary tissues, but lower overall expression of BCL-2 protein was observed in the cell lines derived from our lymphomas compared to the primary tumour cells (Supplementary Fig. 8). This evidence concerns the gene MYC and neoplasm.