MYC and lymphoma: Significantly, we found that all cell lines derived from sgBcl-2 lymphomas were sensitive to venetoclax treatment (mean IC50 = 0.11 μM), which is in striking contrast to the resistance to venetoclax (mean IC50 > 1 μM) observed in lymphomas that arise in Eμ-Myc transgenic mice (Fig. 5d and Supplementary Fig. 10 a, b and Supplementary Table 1).