In addition, our research suggested that the miR-596-3p could promote brain metastasis of NSCLC by inducing the expression of two essential genes in the brain metastasis process, YAP1 and IL-8, which together promote the increase in the penetration of tumor cells in the brain and act as a potential therapeutic target for brain metastasis intervention. This evidence concerns the gene CXCL8 and non-small cell lung carcinoma.