MGMT and glioma: In terms of the pathological of gliomas, some mutations will indeed cause cells to continuously enter the cell cycle for mitosis, escape apoptosis, contact inhibition and immunosuppression and make cells continuously obtain energy so as to cause metabolic abnormalities and induce angiogenesis, hypoxia and necrosis of brain tumours, such as IDH mutation, H3K27M mutation, TERT mutation, MGMT mutation and so on.