Supporting an altered balance of pro- and anti-inflammatory B cells in human obesity, it has also been demonstrated that upon culture with CpG (a ligand for Toll-like receptor 9) and an agonistic anti-BCR antibody, isolated B cells from obese individuals had higher production of IL-6 and lower production of IL-10 compared to lean subjects [36]. The gene discussed is IL10; the disease is obesity due to melanocortin 4 receptor deficiency.