One study used a GM strain to deliver IL-10 in a mouse model of chronic irritable bowel syndrome and it was demonstrated a beneficial effect.137 In another study, L. lactis was also used to express IL-27, an immunosuppressive cytokine, and attenuation of colitis in mice was observed.138 A strain of L. lactis engineered to express human pancreatitis-associated protein I (PAP) was also used to prevent intestinal mucositis in mice.139. This evidence concerns the gene IL10 and colitis.