The anti-inflammatory effect associated with the administration of milks fermented by strains of L. lactis that express IL-10 under the control of the XIES was evaluated using a TNBS-induced colitis murine model.140 Milks fermented by strains producing IL-10 in the cytoplasm (Cyt strain) or secreted (Sec strain) showed decreased inflammation in their large intestines with a regulated immune response. This evidence concerns the gene IL10 and colitis.