M1-like macrophages are known to release proinflammatory cytokines and chemokines such as tumor necrosis factor (TNF)-α, interleukin [IL]-1β, and CXCL10 and exert antitumor activity, whereas M2-like macrophages produce anti-inflammatory cytokines such as IL-4, IL-10, and IL-13 and are associated with tissue remodeling, angiogenesis, and immune suppression, leading to tumor development [5,6]. The gene discussed is IL4; the disease is neoplasm.