This is the case of C1 alleles such as HLA-C*08 and-C*12, which have also been related to a better cytotoxic response against SARS-CoV-2 [70] and, accordingly, the presence of HLA-C*08:02 and -C*12:03 was significantly higher in individuals with mild COVID-19 from our cohort. The gene discussed is HLA-C; the disease is COVID-19.