On the contrary, the presence of C2 alleles (HLA-CLys80) such as HLA-C*07:01 and -C*06:02, which are ligands for the inhibitory KIR2DL1 and activating KIR2DS1 [30], would theoretically lead to lower NK inhibition and higher activation would be more beneficial for the clearance of viral infections [73]. This evidence concerns the gene HLA-C and viral infectious disease.