The HLA-C*12:03 allele, linked to mild COVID-19 presentation in our study, contained the second highest number of verified epitopes, i.e., 65 (p <0.001, Fisher exact test), among 20 HLA-C alleles (26 ± 19 epitopes, mean ± standard deviation) in abundant SARS-CoV-2 proteins. This evidence concerns the gene HLA-C and COVID-19.