Irrespective from promoter DNA methylation status, relative expression data (fold change, FC) showed a significant upregulation of SOCS3 (Wilcoxon rank sum test, p ≤ 0.05), ITGAL (Wilcoxon rank sum test, p ≤ 0.05), NFIC (Wilcoxon rank sum test, p ≤ 0.05), NCOR2 (Wilcoxon rank sum test, p ≤ 0.05), and PGK1 (Wilcoxon rank sum test, p ≤ 0.05) mRNA levels in PAH patients vs. This evidence concerns the gene SOCS3 and pulmonary arterial hypertension.