We also noted that SOCS3 hypomethylation was negatively associated with RAP (red signal) and positively associated with CI (blu signal) in both IPAH (|r|= -0.4 and |r|= 0.6, respectively) and Associated-PAH (|r|= − 0.2 and |r|= 0.7, respectively) patients suggesting a potential prognostic biomarker. This evidence concerns the gene SOCS3 and pulmonary arterial hypertension.