This occurred in 5/10 network-oriented DMGs (SOCS3, ITGAL, GNAS, NR4A2, and GRM2) in IPAH (Fig. 4B) and 7/10 network-oriented DMGs in Associated-PAH (SOCS3, ITGAL, GNAS, NFIC, GRM2, PGK1, and LIMS2) (Fig. 4C). This evidence concerns the gene GRM2 and pulmonary arterial hypertension.