To this aim, the group created a TMEM16F−/− P2X7−/− double knockout (DKO) T cell lymphoma (WR19L) cell line, which they transformed with the murine P2X7k variant, the predominant splice form of P2X7 in WR19L WT cells [4] which is also more sensitive to ATP [5]. The gene discussed is P2RX7; the disease is T-cell non-Hodgkin lymphoma.