EPCAM and breast cancer: The impact of drug-loaded membrane-wrapped nanocages against 4T1 tumors in mice was also shown by Zhu et al. who loaded nanocages with PTX and wrapped the NPs with RBC membranes that were modified with anti-EPCAM (epithelial cell adhesion molecule) antibodies to allow the NPs to actively target EpCAM transmembrane proteins that are overexpressed in breast cancer [48].