These characteristics were not significantly different from those of known treatment naïve EGFR mutated NSCLC without SQ transformation in previous reports.[32,33] Moreover, the time from EGFR-TKI initiation to SQ transformation was 4 to 116 months (median duration, 18 months), indicating a trend toward a slightly longer treatment period than that known for EGFR-mutated NSCLC. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.