Although ARDS is the major cause of mortality in COVID-19 patients, the intense inflammation that occurs with SARS-CoV-2 infection is characterized by increased cytokine release and numerous organ failures, all of which contribute to poor outcomes.[14] In a retrospective study of Italian patients diagnosed with COVID-19, the clinical impact of hyponatremia and its association with IL-6 levels was investigated.[14] Upon admission, over 50% of the patients had low serum sodium concentrations. This evidence concerns the gene IL6 and Hyponatremia.