IL6 and Hyponatremia: It was noted that the high interleukin-6 level impairs the osmoregulatory mechanism of ADH in the brain, causing hyponatremia.[30] Increased serum IL-6 concentration mediates the release of central vasopressin hormone.[31] It was reported that 17 out of 29 patients with hyponatremia who were confirmed to have SARS-CoV-2 infection, their serum IL-6 level was typically high and inversely related to the serum sodium concentration, whereas the level of serum sodium was directly related to PaO2/FiO2.