Inflammatory markers such as interleukin-6 (IL-6) appear to increase in SARS-CoV-2 infection, and its level is directly related to hyponatremia and the rate of mortality.[14] Other electrolyte disturbances have been reported as severe SARS-CoV-2 infections, including hypokalemia and hypocalcemia[15]; however, serum sodium significantly affects the outcome of COVID-19 treatment.[16,17]. The gene discussed is IL6; the disease is COVID-19.