+ + 96 T> C is a silent mutation that does not cause any change in the Hb level in neither heterozygous nor homozygous states, but its compound heterozygosity with beta-thalassemia mutations increases the severity of beta-thalassemia.[24] The possible relationship of this mutation with erythrocytosis needs further investigation. Here, GSTM1 is linked to Beta-thalassemia.