There is growing evidence that immune cell infiltration is crucial in immunotherapy and clinical response and that it affects tumor occurrence and development.[30–33] CD4+ T cells recognize cancer antigens while activated M1 macrophages suppress tumor growth.[34] Here, we found that the GIV expression positively correlated with invasion by B cells, dendritic cells, CD8+ T cells, macrophages, CD4+ T cells, and neutrophils, demonstrating that GIV has prognostic value and may reflect immune status. This evidence concerns the gene CD4 and cancer.