CCDC88A and neoplasm: It is also known as Akt phosphorylation enhancer, Girdin (microfilament attachment protein), or hook-associated protein 1.[4–7] As a member of the CCDC88 protein family, it is also named CCDC88A and can bind to and activate GA (GBA).[8] Mounting evidence shows that GIV directly or indirectly regulates tumor immunity and biological phenotype, thereby modulating angiogenesis and tumorigenesis.