E2F4 and neoplasm: Studies have shown that E2F1 is significantly increased in LIHC tissues and is significantly correlated with tumor stages and poor prognosis of patients with LIHC.[35] E1F4 is one of the repressors in the E1F family; microsatellite instability and E2F4 mutation are common in LIHC, indicating that they play an important role in LIHC.[36] MYC is a multifunctional nuclear phosphoprotein and influences cell cycle progression, apoptosis, and cell transformation.