INS and polycystic ovary syndrome: Numerous studies have demonstrated that omega-3 significantly reduces serum triglyceride levels in PCOS patients.[50,51] It seems that an increase in adiponectin levels after supplementation with omega-3 fatty acids, which have antiatherosclerotic, anti-inflammatory, and antidiabetic effects, might improve insulin sensitivity.[52] In muscles, adiponectin stimulates AMPK, which leads to downstream oxidative pathways.[53] By activating the AMPK pathway, insulin control and blood lipid profiles are improved.[54]