MUC5AC and constipation disorder: Others have shown that inflammation was linked to constipation in both animal and clinical studies.[10,31,32,43] In an animal study, Kim et al[32] found that the treatment of Asparagus cochinchinensis to improve chronic constipation acted via the stimulation of anti-inflammatory responses, that is, the recovery of inflammatory cytokines, inflammatory mediators (iNOS), the number of mast cells, and mucin secretion.