β-sitosterol, dousterol, and coumarin are phytoestrogen-like substances that inhibit osteolysis of cartilage and subchondral bone by regulating nuclear factor kappa-B and osteoprotegerin/receptor activator of NF-κB/receptor activatorof NF-κB ligand signaling pathways, maintaining a dynamic balance between bone resorption and bone formation in the subchondral bone of the joint, thereby delaying the progression of arthritis.[24–26] Lignans and isochondroitin dihydroflavonoids are natural flavonoids with strong anti-inflammatory effects. This evidence concerns the gene TNFRSF11B and Arthritis.