The results of fluid shear stress and atherosclerosis enrichment pathway (Fig. 7), AGE-RAGE signaling pathway (Fig. 8), and PPI core protein ranking (Fig. 4) showed that VEGFA and AKT1 are closely related to the development of AS, and maybe the key regulatory proteins of XFZYD in the treatment of AS. Here, RENBP is linked to atherosclerosis.