GSK3B and osteoporosis: Luteolin has been reported to exhibit the antioxidant activity in glucocorticoid-induced osteoporosis by regulating the ERK/Lrp-5/GSK-3β pathway in vivo and in vitro.[25] Notably, these active components synergistically exert antiinflammatory, maintenance of estrogen level and antioxidative stress bone formation, which can be regarded as potential therapeutic strategies on OP.