Inhibition of MCP-1 or specific MCP-1 antagonist can inhibit the release of TNF-α, IL-1β, and IL-6 from macrophages.[29] In this study, we found that the plasma levels of TNF-α, IL-1β, and IL-6 in the T2DM combined with sepsis group were significantly higher than those in the control group, and the levels of these cytokines also increased with the severity of sepsis. This evidence concerns the gene IL6 and type 2 diabetes mellitus.