MCP-1 plays a key role in regulating monocyte chemotaxis and endothelial activation, as well as regulating the progression of inflammation and the production of proinflammatory cytokines.[23] Lee et al[24] have reported that the MCP-1 rs1024611 polymorphism is associated with Alzheimer disease,[24] asthma,[25] immunoglobulin A nephropathy,[26] lupus nephritis,[27] diabetic nephropathy,[28] and diabetic foot ulcer. The gene discussed is CCL2; the disease is early-onset autosomal dominant Alzheimer disease.