IL-17A promotes intervertebral disc degeneration by inhibiting autophagy through activation of the PI3K/Akt/Bcl-2 signaling pathway.[38] The MAPK pathway participates in central sensitization and nociceptive specific signaling in dorsal horn neurons.[39] This study focuses on the PI3K-Akt signaling pathway. This evidence concerns the gene PIK3CA and Intervertebral disk degeneration.