PIK3CA and nutritional deficiency disease: The PI3K-Akt signaling pathway is an important node in mammalian cells that controls cell growth, migration, proliferation, and metabolism, and plays an important role in regulating T cell development, function, and stability.[40] The gene expression results studied by Tian et al show that hypoxia and nutritional deficiency can increase the relative expression of PI3K and Akt genes and inhibit the expression of functional genes.[41] PI3K-Akt signaling pathway has a protective effect on mesenchymal stem cells derived from human nucleus pulposus against hypoxia and nutritional deficiency.