ADAMTS5 and cancer: Previous studies have shown that transfection of chondrocytes and malignant tumor cells with ds-miR-140 downregulated ADAMTS5, thus suppressing cartilage degradation, and progression and metastasis of malignant tumor cells.[15,28] Transfection of the miR-140-3p was also reported to attenuate the joint injury in the rat model of rheumatoid arthritis.[29]