Combining HLA‐DRB1 and HLA‐DRB345 alleles into haplotypes revealed a risk associated with HLA‐DRB3*02‐DR3‐DQ2, while HLA‐DRB3*01‐DR3‐DQ2 was associated with MS at a genotypic level. This evidence concerns the gene HLA-DRB1 and myeloid sarcoma.