Compared with S group, the expressions of Nrf2 nucleus protein, HO-1 total protein, and NQO1 total protein in ischemia heart tissues of DEX group, tBHQ group, and tBHQ+DEX group increased significantly (P<0.05) and were also slightly higher compared with those of C group (P>0.05). The gene discussed is NFE2L2; the disease is ischemia.