In addition to direct and cross‐presentation, dendritic cells (DCs) can present tumor antigens (TAs) to T cells via a hitherto poorly understood mechanism called “cross‐dressing.” DC cross‐dressing involves the acquisition of preformed peptide‐major histocompatibility class I/II (p‐MHC) complexes from cancer cells. This evidence concerns the gene HLA-C and neoplasm.