Furthermore, FUNDC1-involved MAMs can promote calcium transport to cytoplasm, making nuclear factor of activated T cells 1 (NFATC1) dephosphorylated, and then Bmi1 polycomb ring finger oncogene (BMI1) is upregulated, thus promoting the progression of breast cancer (Wu et al., 2019b). The gene discussed is BMI1; the disease is breast carcinoma.