Furthermore, FUNDC1-involved MAMs can promote calcium transport to cytoplasm, making nuclear factor of activated T cells 1 (NFATC1) dephosphorylated, and then Bmi1 polycomb ring finger oncogene (BMI1) is upregulated, thus promoting the progression of breast cancer (Wu et al., 2019b). Here, FUNDC1 is linked to breast carcinoma.