FUNDC1 and cancer: Li et al. (2019a), Li et al. (2019b) pointed out that FUNDC1-LonP1 axis also played an important role in maintaining mitochondrial reprogramming and cellular plasticity in cancer cells (Cappellini et al., 2020). Wang Yue’s study confirmed that the coordination between FUNDC1-mediated mitophagy and unfolded proteins could attenuate inflammation-mediated myocardial injury in septic cardiomyopathy (Wang et al., 2021a).