The mechanism is mainly related to the accumulated ROS in damaged mitochondria, because ROS can activate MAPK, which leads to white adipose tissue insulin resistance and systematic insulin resistance induced by elevated tumor necrosis factor (TNF), interleukin 6 (IL6) and downregulated adiponectin gene (ADIPOQ) (Wu et al., 2019c). Here, ADIPOQ is linked to Insulin resistance.