The levels of N-cadherin proteolytic fragments are increased in the CSF and plasma of AD patients (Choi et al., 2020), while N-cadherin expression is upregulated in the cerebral cortex of Aβ aggregate-injected mice (Kong et al., 2005), suggesting deregulation of N-cadherin expression or cleavage of this glycoprotein in AD. This evidence concerns the gene CDH2 and Alzheimer disease.