RHOT1 gene expression can be found upregulated (pancreatic adenocarcinoma, cholangio carcinoma, esophageal carcinoma, glioblastoma or acute myeloid leukemia and thymoma) as well as downregulated (adrenocortical carcinoma, ovarian serous cystadenocarcinoma, skin cutaneous melanoma). This evidence concerns the gene RHOT1 and pancreatic adenocarcinoma.