TNF and Hypercholesterolemia: With the increase in OS, the high-fat diet led to increased endometrial cell apoptosis by increasing the expression of 8-hydroxydeoxyguanosine (8-OHdG) (Heard et al., 2016); compared with the control group, the high-fat diet in the hypercholesterolemia rat model promoted oxidative and inflammatory stress and significantly increased tumor necrosis factor-α (TNF-α) and F4/80 macrophage infiltration (El-Mansi et al., 2019).