Interestingly, related studies have indicated that LXRβ-knockout mice exhibit anxiety-like behaviors (Tan et al., 2012; Yu et al., 2020) and that rats in which LXRβ is knocked down in the hippocampus by short hairpin RNA (shRNA) exhibit depressive-like behaviors; however, the LXR agonist GW3965 can improve depressive-like behaviors (Peng et al., 2018). Here, NR1H2 is linked to Anxiety.