The top eight anti-HCC core targets are SRC (degree 60), EGFR (degree 58), CASP3 (degree 57), MMP9 (degree 47), mTOR (degree 45), HIF1A (degree 43), ERBB2 (degree 42), and PPARG (degree 38). The gene discussed is HIF1A; the disease is hepatocellular carcinoma.