JAK2 and obesity due to melanocortin 4 receptor deficiency: In another study of obesity-related KOA, Jiang found that RES attenuated obesity-related KOA by attenuating the janus kinase 2 (JAK2)/STAT3 signaling pathway independent of the suppressor of cytokine signaling 3 (SOCS3) pair (Jiang et al., 2020).