The conclusion of the two compounds suppressing NF-κB signaling can be supported by other studies showing that umbelliferone (Ouyang et al., 2019; Wu G et al., 2021) and scopoletin (Li et al., 2009; Chen et al., 2021) can effectively suppress phosphorylation of specific NF-κB subunits (e.g. p65 and IĸBα) and expression of downstream genes (e.g. IL-1β, TNF-α, MMP-3, MMP-9, COX-2, Bcl-2) in RA synovial tissues and FLSs. This evidence concerns the gene PTGS2 and rheumatoid arthritis.