Pseudobulk and single-cell differential expression analysis identified a large number of genes that were significantly upregulated (POSTN, MEOX1/2, TLL1, EDNRA, SVEP1 and FRZB) and downregulated (APOD, NPPC, ANGPTL1, FIGF and ACE2) in DCM samples compared to non-diseased donors. Here, VEGFD is linked to familial dilated cardiomyopathy.