Higher 0.1*age (OR = 1.476, 95% CI: 1.076–2.023, P = 0.016), lower Alb (OR = 0.877, 95% CI: 0.778–0.989, P = 0.032) and anxiety (OR = 3.442, 95% CI: 1.204–9.839, P = 0.021) were independent risk factors for severe sleep disturbance in MHD patients. Here, ALB is linked to sleep disorder.