The lower HDL-C (OR = 0.212, 95% CI: 0.058–0.774, P = 0.019) and Alb (OR = 0.865, 95% CI: 0.778–0.963, P = 0.008) were associated with an increased risk of severe sleep disturbance in MHD patients. The gene discussed is ALB; the disease is sleep disorder.