A recent Mendelian randomization study suggested that renal impairment assessed by higher urine albumin-to-creatinine ratio and decreased eGFR are causally involved in large-artery stroke and SVD (i.e., small-vessel stroke, WMHs, and intracerebral hemorrhage), emphasizing the shared common genetic mechanisms with CKD (100). The gene discussed is ALB; the disease is intracerebral hemorrhage.