TTR and carpal tunnel syndrome: In a prospective study examining men ages ≥50 and women ages ≥60 undergoing CTS surgery (85% of those with bilateral CTS), 10 out of the 98 patients (10.2%) were found to have amyloid deposits, although only seven had TTR amyloid deposition and only two of those patients had TTR mutations (Leu58His and Ala81Thr) (18).