A more recent retrospective study showed for those with TTR amyloidosis (including wild-type and hereditary), the probability of having CTS was the highest during the 5–9 years prior to the diagnosis of cardiac amyloidosis, and that CTS was an independent mortality risk factor in transthyretin amyloidosis (13). This evidence concerns the gene TTR and Familial transthyretin-related amyloidosis.