Figure 1C showed the top 20 expressed lncRNAs among the DELs, including GAS5, SNHG12, SHNG3, and LINC00152. LINC00152 is proposed as a key oncogenic lncRNA in human cancers, and the elevated LINC00152 expression was significantly associated with poor prognosis in multiple cancer types (Liang et al., 2018). To validate the RNA sequencing results, we performed a qRT-PCR assay after incubating HCT116 or a human embryonic kidney cell HEK293T with live S.typhimurium. Consistently, LINC00152 was significantly upregulated in the S.typhimurium-treated HCT116 and HEK293T cells (Figures 1D, E). The gene discussed is SNHG12; the disease is cancer.