We found that ORFV NA1/11 infection enhanced CXCL16 expression and secretion in lung cancer cells and co-culture of T cells from WT mice, but not from CXCR6-/- mice, with ORFV NA1/11-infected lung cancer cells promoted the migration of CD8 T cells in a transwell experimental system. The gene discussed is CXCR6; the disease is lung cancer.