MAPT and early-onset autosomal dominant Alzheimer disease: We performed a systematic review and meta-analysis in order to test the accuracy of plasma tau protein in diagnosing Alzheimer's disease (AD) or mild cognitive impairment (MCI).<h4>Methods</h4>We searched PubMed, Cochrane, Embase and Web of Science databases, and conducted correlation subgroup analysis, sensitivity analysis and publication bias analysis using R Programming Language.<h4>Results</h4>A total of 56 studies were included.